Automated Quantitative 3-Dimensional Modeling of the Aortic Valve and Root by 3-Dimensional Transesophageal Echocardiography in Normals, Aortic Regurgitation, and Aortic Stenosis

title:: Automated Quantitative 3-Dimensional Modeling of the Aortic Valve and Root by 3-Dimensional Transesophageal Echocardiography in Normals, Aortic Regurgitation, and Aortic Stenosis

publisher:: American Heart Association

people:: Anna Calleja, Paaladinesh Thavendiranathan, Razvan Ionasec, Helene Houle, Shizhen Liu, Ingmar Voigt, Chittoor Sai Sudhakar, Juan Crestanello, Thomas Ryan, Mani A. Vannan

organization:: Siemens Corporate Research, The Ohio State University, The Ohio State University Wexner Medical Center

domain:: Medical Imaging, Clinical Applications, Cardiology

link:: https://doi.org/10.1161/circimaging.112.976993

citations:: 97 (OpenAlex) · 99 (Semantic Scholar) — as of 14 October 2026

publications

Article record — Europe PMC.

Summary

The clinical validation study: taking the automated 3D aortic root model into a cardiology journal and testing it against the measurements clinicians actually make. Automated modelling from 3D TEE and CT is compared with 2D TEE and with targeted 2D measurements derived from the 3D data, in patients without valve disease and then across three abnormal groups - severe aortic stenosis, dilated root without regurgitation, and dilated root with regurgitation.

The finding that matters for transcatheter planning: automated 3D annular diameters are systematically larger than the 2D measurements, and the parameters that show no difference in normal subjects separate significantly in disease. Reproducibility was excellent across all parameters.

Data Points

• Automated 3D modelling compared against 2D TEE and targeted 2D in normals (n=20 3D TEE, n=20 CT)
• Disease groups: severe aortic stenosis (n=14), dilated root without AR (n=15), dilated root with AR (n=20)
• Automated 3D TEE sagittal annular diameter significantly greater than 2D TEE (P=0.004); same for 3D TEE and CT coronal diameters (P<0.01)
• Sinotubular junction and sinus of Valsalva diameters: no 2D/3D difference in normals, significant difference in abnormals
• Intercommissural distance, leaflet length and height all separated the abnormal group significantly
• Excellent reproducibility for all parameters; directly relevant to surgical and transcatheter intervention planning

Reference

Circulation: Cardiovascular Imaging 6(1):99-108, 2012. doi:10.1161/circimaging.112.976993 · PubMed 23233743

97-99 citations (OpenAlex / Semantic Scholar, October 2026)

Part of the complete record in Scientific Publications - Peer-Reviewed Research Record.